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Paper Details

Synthesis and Investigation of Antibacterial activity of Some Schiff bases

Shipra Baluja1* and Sumitra Chanda2

Journal Title:Journal of Chemical, Biological and physical sciences

Eight Schiff bases were synthesized from 4-amino benzoic acid and were characterized by IR and NMR spectral analysis. In all 8 compounds were synthesized viz. (1) 4-[(4-Methoxy-benzylidene)-imino]- benzoic acid, (2) 4-(Benzylidene-imino)-benzoic acid, (3) 4-[(2-chloro-benzylidene)-imino]-benzoic acid, (4) 4-[(Furan-2-ylmethylene)-imino]-benzoic acid, (5) 4-(3-Phenyl-allylideneimino)-benzoic acid, (6) 4- [(2-Hydroxy-benzylidene)-imino] -benzoic acid, (7) 4-[(4-Hydroxy-3-methoxy-benzylidene)-imino]- benzoic acid and (8) 4-[(3-Nitro-benzylidene)-imino]-benzoic acid. Antibacterial activities of these synthesized Schiff bases have been tested against six bacterial strains. The studied bacterial strains are S. aureus ATCC 25923, B. cereus ATCC 11778, P. mirabilis NCIM 2241, P. aeruginosa ATCC 27853, S. typhimurium ATCC 23564 and A. fecalis ATCC 8750. The antibacterial activity was done by Agar Ditch method. The solvents used for studying antibacterial activity were 1, 4-dioxan (non-polar) and DMF (polar, Dimethylformamide). A differential effect of the compounds was found in the bacterial strains investigated and the solvents used, suggesting once again that the antibacterial activity is dependent on the molecular structure of the compound, solvent used and the bacterial strains under consideration.