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Paper Details

Biochemical and histological responses on the liver of adult wistar rats fed with varied level of cassava

F. B. Oyeyemi1*, S. A. Babajide2, T. K. Elelu3, W. A. Oyeyemi4 and O. A. Iyiola5,6

Journal Title:Journal of Chemical, Biological and physical sciences

The biochemical and histological responses on liver of rats following feeding on unprocessed cassava was examined in this study. Twenty-eight rats were randomly divided into four. Group A, which served as the control was fed with 30 grams of grower feed per day, while groups B, C and D were given 10 grams of unprocessed cassava and 20 grams of grower feed per day, 20 grams of unprocessed cassava and 10 grams of grower feed per day and 30 grams of unprocessed cassava per day respectively. After feeding for six weeks, the animal weight, liver histology, aspartate amino transferase (AST), alanine amino transferase (ALT), gamma glutamyl transpeptidase (GGT) and alkaline phosphatase (ALP) were measured. The result shows significant reduction in weight gain among groups B, C and D animals when compared with the control. Histological studies also revealed diffused hepatic degeneration of the liver in all treatments except the control; this damage is more evident in group D animals. There was a significant increase in ALP, AST, ALT and GGT activity in groups B, C and D when compared with the control group, the highest was observed in group D. Biochemical evidence of tissue injury in the liver was supported by histological findings of the liver which showed disturbance of normal hepatic cytoarchitecture on rats in groups B, C and D. It is concluded that feeding on unprocessed cassava is harmful to the liver.