Synthesis and Characterization of2-[1H- benzimi - dazole-2yl-sulfanyl]-N-[(E) - (3-methylphenyl) methylidene] acetohydrazide
Journal Title:Journal of Chemical, Biological and physical sciences
Many important biochemical compounds and drugs of natural origin
contain heterocyclic ring structures. Among these e.g. Carbohydrates, essential amino
acids, vitamins, alkaloids, glycosides etc. the presence of heterocyclic structures in
such diverse types of compounds is strongly indicative of the diverse types of the
pharmacological activity. Diversity of biological response profile has attracted
considerable interest of several researchers across the globe to explore this skeleton for
its assorted therapeutic significance. By using different synthetic methods new
benzimidazole derivatives were synthesized and further Melting points were
determined by using Precision melting point apparatus in open capillaries and are
uncorrected. The purity of the compounds was checked by TLC on silica gel G plates
using n-Hexane, ethyl acetate (1:3) and methanol: chloroform (1:9) solvent system. The
synthesized benzimidazole derivatives were characterized by IR spectral analysis.
Benzimidazole is a lead nucleus for future developments to get effective compounds.