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Paper Details

Synthesis and Antimicrobial Activity of Pyrimidin-2-Thiones

M.L.Leuva1,V.M.Barot1 and Vikesh Agrawal2

Journal Title:Journal of Chemical, Biological and physical sciences

Title compounds 2-pyrazoline have been prepared by reaction of 1-(4- methyl-2, 5-dimethoxyphenyl)-3-(substituted-phenyl)prop-2-en-1-one(1a-e)which on treatment with hydrazine hydrate in presence of propionicacid to give 4-(2,5- dimethoxy-4-methylphenyl)-1-(4-methylphenyl)-6-substitutedphenylpyrimidine- 2(1H)-thione (2a-e). The structural assignment of the compounds was based on elements analysis and IR, 1H NMR and Mass spectral data. All the synthesized compounds have been screened for their antimicrobial activity to gram-positive and gram-negative bacterial strains and antifungal activity. The antimicrobial activities of the synthesized compounds have been compared with standard drugs like Amoxycillin, Ciprofloxecine and Griseofulvin. Purity of synthesized compounds have been checked by TLC.