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Paper Details

Studies on Chalcone Derivatives Antioxidant and Stability Constant

R. Ravichandran, M. Rajendran*, D. Devapiriam

Journal Title:Journal of Chemical, Biological and physical sciences

The drug cis-platin development has raised new issues like metal complexes in biochemistry. The modeling of their biochemical properties involves the accurate determination of thermodynamically data, like stability constants. The chalcone 2-hydroxychalcone and 2-hydroxy-3,4-dimethoxychalcone have been synthesized and characterized with FT-IR,1H-NMR, 13C-NMR spectroscopic techniques. By using UV visible spectroscopy method the mole fraction ratio for Copper, Nickel and Zinc with 2-hydroxychalcone and 2-hydroxy-3,4- dimethoxychalcone complexes were determined and it was found to be 1:1. The stability constants of this complex have been determined by Jobs method. The stability constant (Kf) of Copper, Zinc and Nickel with 2-hydroxychalcone complexes in acetate buffer pH = 4.4 were determined to be 8.8 x 105 , 1.34 x 105 and 5.6 x 105 respectively. The Kf of Copper, Zinc and Nickel with 2-hydroxy-3,4- dimethoxychalcone were determined at the same pH and that the values are 5.2 x 105 , 5.4 x 104 and 2.5 x 104 respectively. Antioxidant activity of these chalcones was evaluated by using 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2-Azino-bis (3-ethylbenzothiazoline-6-sulfonic acid (ABTS) radicals scavenging methods, which showed that the antioxidant activity of 2-hydroxychalcone has higher value than the 2-hydroxy-3,4-dimethoxychalcone. Semi-empirical study results shows that2-hydroxychalcone have higher dipole moment than 2-hydroxy-3,4-dimethoxychalcone.