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Paper Details

Synthesis and Antimicrobial Activity of Azetidin-2-one Containing Acetyl Pyrazoline Derivatives

Shailesh H.Shah*1, Niraj Shah3, Pankaj S.Patel2

Journal Title:Journal of Chemical, Biological and physical sciences

Pyrazolines are very important Nitrogen containing five member heterocyclic chemical compounds and various methods have been worked out for their synthesis. A new series of 4-(4-Chloro phenyl)-3-chloro-1-{4-[5-(Substituted phenyl)-1-acetyl-4,5-dihydro-pyrazol-3-yl]phenyl}azetidin-2-one are synthesized by reacting 3-chloro-1-{4-[5-(Substituted phenyl)-4,5-dihydro-pyrazol-3-yl]phenyl}-4- (4-Chloro phenyl)azetidin-2-one (0.001M) with Acetic Acid in presence of Pyridine. All these compounds were characterized by means of their IR, 1H NMR, Spectroscopic data and pharmaceutical analysis. All the compounds were tested for their antibacterial and antifungal biological activities by broth dilution method