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Paper Details

Polyethylene Glycol: Support as a Catalyst in the Synthesis of Novel Thiophene Chalcones

Asha Lavania *, Manju Yadav, Kiran Dasary and Anita V K Anand

Journal Title:Journal of Chemical, Biological and physical sciences

Chalcones with Excellent yields and purity were obtained in short time duration in the presence of Polyethylene glycol (PEG-400) which acted as a soluble polymer support and catalyst at low temperature. In present work, a series of novel chalcones (a-h) were prepared by Claisen-Schmidt condensation, by the reaction of 2-acetyl-5-chloro thiophene with different aromatic aldehydes in the presence of aqueous solution of sodium hydroxide, ethanol and PEG 400 used as a catalyst at room temperature. The structures of the various synthesized compounds are assigned on the basis of elemental analysis, IR, 1 HNMR and mass spectral data.