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Paper Details

Treatment Strategies against Female Reproductive Lead Toxicity: A Review

Ragini Sharma and Khushbu Panwar*

Journal Title:Journal of Chemical, Biological and physical sciences

Environmental endocrine disruptors have been at the heart of discussion about chemicals and their effects on fertility, but the focus on the heavy metals and the role of antioxidants during developing stages has been largely overlooked. Lead induced oxidative stress contributes to the pathogenesis of lead poisoning by disrupting the delicate pro oxidant or antioxidant balance that exists within mammalian cells. The role of chelating agents in lead poisoning is controversial. Most of the chelating agents tend to have adverse side effects and the benefits are transitory. The chelating agents cannot be used during developing stages as this period is highly sensitive to these agents and chelators have concomitant and injurious side effects on development. The assumption of oxidative stress as a mechanism in lead toxicity suggests that antioxidants or vitamins might play a role in treatment of lead induced toxicity. In the present review methods of screening for sub-clinical lead poisoning along with dietary treatment and prevention are discussed.