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Paper Details

Formation of Transition Metal Complexes Carrying MedicinalDrugs: Thermodynamic Study

ShailendrasinghVirendrasinghThakur, Mazahar Farooqui2and SahebraoD. Naikwade3

Journal Title:Journal of Chemical, Biological and physical sciences

Stability constant of Isoniazidand Imipramine Hydrochloridedrugs with transition metal ions Fe, Co, Ni, Cu, Zn and Cd have been determined by using a pH metric titration technique in 20% (v/v) ethanol-water mixture at three different temperatures (25 C, 35 Cand 45 C) and at an ionic strength of 0.1M NaClO4. The method of Calvin and Bjerrum as adopted by Irving and Rossotti has been employed to determine metal-ligand stability constant logK values. It is observed that transition metal ion forms 1:1 and 1:2 complexes. The thermodynamic parameters such as, Gibbs free energy change (?G), entropy change (?S) and enthalpy change (?H) associated with the complexation reactions were calculated. The formations of metal complexes were found to be spontaneous, exothermic in nature and favorable at lower temperature.