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Paper Details

Synthesis and Potentiometry Determination of Stability Constant of Binary Complex of Tetrapeptide TFA.Ala- Phe-Pro-Leu-OH with D-Block Transition Metals

Sanjay N. Aher a, b,*, Supriya S. Aher b, S. D. Rathod a.

Journal Title:Journal of Chemical, Biological and physical sciences

Tetrapeptide TFA. Ala-Phe-Pro-Leu-OH synthesized by using Solid phase peptide synthesis (SPPS). Proton-ligand formation constant (pK) of tetrapeptide have been evaluated by potentiometry measurements using Calvin-Bjerrum titration technique as used by Irving and Rossotti. The binary complex of Ni (II), Mn (II), and Fe (II) with tetra peptide are examined at varying temperature and ionic strength conditions in aqueous media. The stability of tetrapeptide metal complex with dblock transition metals follow the Irving-Williams order and shows inverse trend with varying temperature and ionic strength conditions.