Relevance of IL-4, IL-5 and IL-6 in Women withToxoplasmosis in Erbil.
Sawsan M. Al-Sorchee, Nasir I. Khatab, Cihan University, College of Science, Biology Department, Salah-Aldeen University, College of Education, Biology Department.
Journal Title:Aalborg Academy Journal of Medical Sciences
Background: Toxoplasmosis is a common infection in women with child bearing age and may attribute to bad obstetric outcomes. Aim: This study was conducted to evaluate IL-4, IL-5 and IL-6 levels in women with toxoplasmosis and their relevance to this infection. Materials and Methods: Sixty eight women were included in this study with a history of abortion (single or repeated). They were referred to by physicians from different hospitals and private laboratories in Erbil/ Kurdistan region of Iraq from March 2010 until March 2011 for the detection of antitoxoplasma antibodies and 30 healthy women were selected as control. Venous blood samples were collected from these women; serum was obtained for ELISA test for the detection of anti- toxoplasma IgG and IgM. Levels of IL-4, IL-5 and IL-6 in these women were also detected. Results: Fifty one women (75%) who had a single or repeated abortion were infected with Toxoplasmosis and had positive ELISA tests. From those, eleven (21.6%) had IgM, twenty five (49%) had IgG and fifteen (29.4%) had both IgM and IgG. The levels of IL-4, IL-5 and IL-6 were significantly high compared to the control. Conclusion: Cellular immune response was highly involved during acute and chronic Toxoplasmosis.