THESIS ABSTRACT: Effect of Leptin and its Association with Steroid Hormones and Lipid Profile in Diabetic Subjects.
Sura Zahim Hussain Alsamarai, Tikrit Teaching Hospital, Salahuldean Health Authority, Tikrit, Salahuldean Governorate, Iraq. A Ph D thesis conducted in Tikrit University College of Science, 2012, under the supervision of Professor Dr. Abdulmonem Hamad Alsamarai, Samara University College of Education [SUCOE], and Samara, Iraq.
Journal Title:Aalborg Academy Journal of Medical Sciences
Background: Diabetic mellitus is a chronic non curable disease with high prevalence globally. The disease associated with inflammatory responses and metabolic changes and subsequently these responses lead to a multiple organ complications. However, these complications development may be prevented through good diabetic control. Biochemical changes monitoring is the main effective approach in such control program. Aim: To determine the role of leptin, steroid hormones, and lipid profile in the pathogenesis of diabetes mellitus and clarify their uses in disease control program. Materials and methods: Serum samples collected from 220 individuals, 100 of these individuals were normal and 120 cases were diabetic patients admitted to Tikrit Teaching Hospital in Tikrit city from January 2010 to June 2011. The study population age ranged from (12-70) years. Patients and controls had hormonal assay of Leptin, LH, FSH, PRL, Estrogen, Progesterone, Testosterone, Cortisol, Glucose and Lipid profile, these samples were divided into four groups of diabetic patients and controls. Group 1 (Diabetic ketoacidosis in pubertal age), Group 2 (Poorly controlled D.M in adult age), Group 3 (Postmenopausal D.M women & men) and Group 4 (Gestational diabetes mellitus) the fifth group (control group) subdivided into four groups each one included with each group of diabetic patients. Results: Leptin increased progressively with aging in diabetic patients as compared with controls and in female in comparison with male. It increased extensively in three trimesters of gestational diabetic women more than control. LH and FSH decreased in diabetic patients to a lesser degree than control in all groups, while Prolactin also decreased in diabetic patients in all age groups except in male of group one and female of groups one and two.