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Paper Details

Antifungal Activity of Nine Plant Oils Against Local Rhodotorula Species and Scytalidium dimidiatum

Salah Mahdi Al-Bader, Knowledge University, College of Science, Pathological Analysis Department. Erbil, Iraq.

Journal Title:Aalborg Academy Journal of Medical Sciences

Background: Although there is a development in the production of new antimicrobial agents, however, the new antifungal agents development still limited. One of the approach to overcome such obstacle is to use plants products as antifungal agents. Aims: The study was conducted to demonstrate the antifungal activity of pharmaceutical crude oils of nine medicinal plants on Rhodotorula species and Scytalidium dimidiatum. Materials and methods: Local fungal isolates of Rhodotorula species (yeast) and Scytalidium dimidiatum (filamentous) were isolated from sheep wool in Erbil city. Pure cultures were prepared on Sabouraud's dextrose agar (SDA). SDA supplemented with 1% (v/v) of plant oils was used for primary screening of oils antifungal activity. Macroscopic characteristics of yeast cultures and radial growth of mold were screened for the primary determination of the oils effectiveness. The tested oils include that of Zingiber officinale (Ginger), Sisymbrium officinale (Hedge), Peganum harmala (Harmel), Rosmarinus officinalis (Rosemary), Pimpinella anisum (Anise), Cuminum cyminum (Cumin), Salvia officinalis (Sage), Linum usitatissimum (Flax), and Allium sativum (Garlic). Results: Oils of R. officinalis, A. sativum and S. officinale exhibited the highest antifungal activity on Rhodotorula species and S. dimidiatum. The rest treatments except Z. officinalis showed a moderate antifungal effect. While Z. officinalis not demonstrated antifungal activity. The minimum inhibition concentration (MIC test) of garlic, rosemary, and hedge oils showed that garlic was the only treatment that inhibited the growth of tested isolates in all concentrations, while the rosemary and hedge oils showed a diverse activity levels. Conclusions: The effectiveness of the tested oils on fungal isolated demonstrated variable antifungal activities and the effectiveness was higher on the yeast growth rather than on filamentous fungi. Additionally, Rodotorula species was more sensitive to the tested oils S. dimidiatum. Key words: Rhodotorula, Scytalidium, plant's oils, antifungal, Iraq.