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Paper Details

STUDY OF PREVALENCE AND MICROBIAL RESISTANCE RATES AT A PUBLIC HOSPITAL IN RIO DE JANEIRO CITY

Marcus Vinicius da Silva Coimbra, Marcus V. da Silva Coimbra Filho, Nádia Cristina de Lima

Journal Title:Revista de Divulgação Científica Sena Aires
Abstract


Abstract: Antimicrobial resistance among bacterial pathogens is a global problem, but in Brazil data are sparse. This study analyzed the prevalence and resistance rates of the main microorganisms isolated of biologic materials from patients in Intensive Care Unit (ICU) and Non – Intensive Care Unit (N-ICU) at Brazilian Air Force Central Hospital (HCA), during 2005. At microbiologic laboratory, standard methods were used for identification and susceptibility testing. In addition, quality controlled strains were utilized, routinely, to ensure accurate performance of the assays. The analysis of data demonstrated the presence of high resistance rates in most of the bacteria studied. It suggests that resistance, among gram-positive and gram-negative bacilli, is common and significant in hospital studied. The isolates from ICU patients presented resistance patterns higher than those from UI. Resistance rates among Staphylococcus sp. were high but similar those found around the world. The Methicillin-Resistant Staphylococcus aureus (MRSA) prevalence was 26% and 77% when the isolates came from N-ICU and ICU, respectively. In spite of resistance to most relevant antimicrobial has been common among gram-negative bacilli, the majority remained susceptible to imipenem. Particularly alarming are the high resistance rates, presented by K. Pneumoniae from ICU and N-ICU and E.coli from NICU, probably because of the extended-spectrum -lactamases (ESBL) enzyme. These results have important implications for physicians at HCA, with regard to empirical antibiotic selection. They also have important implication for authorities involved in hospital management, as well as in the development of policies regarding antibiotic utilization, infection control and public healthcare.

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