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Paper Details

Simultaneous Determination of Ranitidine Hydrochloride and Ondansetron Hydrochloride in Bulk Drug and Tablet Dosage Form by UV Spectrophotometry

Priya BD, Lakshmi BV, Bhavya V, Ramya V, Aparna D, Prasanthi T and Rao AL*

Journal Title:Open Access Journal of Pharmaceutical Research

A simple, accurate and economic UV Spectrophotometric method was developed for simultaneous estimation of Ranitidine Hydrochloride (RNH) and Ondansetron Hydrochloride (ODH) in bulk drug and tablet dosage form. Distilled water was used as solvent for analysis. The wavelengths selected for determination of Ranitidine was found to be 227.8 nm and for Ondansetron was found to be 248.7 nm. The linearity was found to be satisfactory in the concentration range of 2-10 µg/ml for both RNH and ODH. Regression analysis reveals that the correlation coefficient was found to be 0.9976 for RNH and 0.9979 for ODH. The %RSD values for intra-day precision and inter-day precision for Ranitidine were found to be 0.58% and 0.96% and for Ondansetron were found to be 0.44% and 0.54% respectively. The mean recovery of the drugs RNH and ODH was 99.36% and 99.51% respectively. The proposed method was validated as per ICH guidelines and the results are in accordance with acceptance criteria. Hence the present described method can be identically used for analysis of Ranitidine Hydrochloride and Ondansetron Hydrochloride in commercial formulation.