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Paper Details

Antifungal Effect on Candida Albicans of Laurel, Coconut and Coriander Seed Oil

Cansel C*, Huseyin HD, Seyma AB, Ali G, Sidika BO, Yasemin G, Beril K, Hale Feyza B and Mevlut B

Journal Title:Open Access Journal of Pharmaceutical Research
Abstract


Candida albicans (C.P. Robin) mushroom has the highest pathogenicity among other candida species. The high amounts of linoleic acid (18:2), and oleic acid (C 18: 1, 9 octadecenoic acid) in the biphasic mutant fungus Candida albicans in vitro by using cold press method from Laurel and Coriander seeds, and (-)-isopulegol monoterpen component were cultured in the microbiology laboratory of the ZadeVital R&D center. Kirby-Bauer disc diffusion method was used in the passages. The proportions of fatty acids were measured by GC (Gas Chromatography), and the free fatty acids by GC MS (Gas Chromatogram-Mass Spectrometry). The oils extracted from the bay and coriander seeds by cold pressing were absorbed into sterile antibiotic discs. Nystatin antibiotic was used as a reference. Antibiograms were checked every 2 days for 24 hours. The zones formed in the passages were measured in mm and resistance and sensitivity analyzes were performed against Candida albicans strain oils. We have found that (-)-isopulegol monotherpen is a determinant of antifungal properties compared to other fatty acids. In this study, we have seen that oils extracted by cold pressing from laurel and coriander seeds have topical antifungal properties on Candida albicans species.

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