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Paper Details

Coronavirus Disease-2019 (COVID-19): A Review of the Literature

Shirin Tarafder.

Journal Title:Acta Scientific Microbiology

The ongoing outbreak of coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Fourteen mutations have been identified in Spike protein of SARS-CoV-2 of which mutation D614G is of urgent concern; that may have originated either in China or Europe, and which is now the dominant pandemic form in many countries. Although most patients have mild symptoms and good prognosis after infection but can result in severe and even fatal respiratory diseases such as acute respiratory distress syndrome (ARDS), can die of multiple organ failure. It still remains unclear regarding the pathogenesis of SARS-CoV-2 infection in humans. Innate immune response is the early defense against viral infections, and when it is dysregulated, results in an exaggerated inflammation, may cause death. The information on immune response to SARS-CoV-2 is not well documented. The cytokine storm may be responsible for severity of the disease. There is a growing understanding of SARS-CoV-2 in the virology, immunological changes, potential pathogenesis, disease progression and clinical management strategies. This review has summarized the current knowledge on the updated approaches regarding COVID-19 based on the emerging basic and clinical data