Novel Corona Virus COVID-19: An Overview
Rohini Agrawal, Prashant Amale and Shilpa A Deshpande.
Journal Title:Acta Scientific Microbiology
Virus Disease of 2019 (COVID-19), was proclaimed as a pandemic emergency by World Health Organisation (WHO) in March 2020. The main causative factor behind the pneumonic viral infection is Severe Acute Respiratoty Syndrome Coronavirus - 2 (SARS-CoV-2) which holds the 75 - 80% nucleotide sequence similarity with SARS-CoV. Infected and asymptomatic individual are the primary source of human to human transmission due to it become a pandemic, the women with third trimester is also susceptible to this respiratory and pneumonic infection. The time period for the infection is 14 days and the average duration is of 20 days. The infection is clinically manifested mainly by fever, shortness of breath, Acute Respiratory Distress Syndrome (ARDS) etc. Various diagnostic approaches such as Nucleic Acid Amplification Test (NAAT) by using RT-PCR, serological testing etc had been used among which RT-PCR found to be suc-cessful in the detection of strain of SARS-CoV-2. Present review focus on the genomic structure of SARS-CoV-2, mechanism, transmis-sion, entry into the host cell, diagnosis, and prevention of the Covid-19. This may be helpful for the development of therapeutic agents used for prophylaxis and treatment of SARS-CoV-2