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Paper Details

DEVELOPMENT AND VALIDATION OF STABILITY INDICATING RP-HPLC METHOD FOR DETERMINATION OF OLANZAPINE IN PHARMACEUTICAL DOSAGE FORMS

Sunil Yadav, prakash pant, Vaibhav Verma

Journal Title:International Journal of Medical Studies
Abstract


Background: Spectrophotometric analysis fulfils requirement where the simultaneous estimation of the drug combination can be done with similar effectiveness as that of chromatographic methods. Simultaneous estimation of drug combination is generally done by separation using chromatographic methods like HPLC, GC and HPTLC etc. These methods are accurate and precise with good reproducibility, but the cost of analysis is quite high owing to expensive instrumentation, reagent and expertise. Hence it is advisable to develop simpler and cost-effective method for simultaneous estimation of drugs for routine analysis of formulation. Methods: A descriptive study design was used and information was obtained through various literature reviews. RP-HPLC method was used and data was analyzed. Conclusion: The developed stability indicating HPLC method for quantitative estimation of olanzapine in bulk and pharmaceutical dosage forms is fast, simple, accurate, and more precise. Validation of this method was accomplished, getting results meeting all requirements. Thus, the developed HPLC method can be used for routine quality control test.   Keywords: Chromatography, RP-HPLC, Spectrophotometric, Simultaneous estimation.

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