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Paper Details

Study of Antibiotic Resistance against Fourth Generation Cephalosporins in Escherichia coli

Mehwish Saleem

Journal Title:Acta Scientific Microbiology
Abstract


The large majority of antibiotics currently used for treating infections and the antibiotics resistant genes acquired by human pathogens are gaining resistance against antibiotics day by day. Fourth generation cephalosporins are β-lactam antibiotics, pos-sess an extra ammonium group, which allows them to rapidly penetrate through the outer membrane of Gram negative bacteria, Escherichia coli; enhancing their activity. Enteric Escherichia coli are both natural flora of human and important pathogen causing significant morbidity and mortality worldwide by acquiring resistance. The resistance profile of Escherichia coli may be sensitive or highly resistant. To test resistance (n = 60) samples were used. These clinical samples helped in evaluation of sensitivity and resis-tance against fourth generation cephalosporin in Escherichia coli. Gram staining and various morphological as well as biochemical test were performed to identify Escherichia coli. From (n = 60) samples, (n = 32) 53% samples showed resistance against Cefepime. In these resistant strains most of them were females (n = 35) and remaining of males (n = 25). It indicates high onset of fourth genera-tion cephalosporin resistance in Escherichia coli. From (n = 60) samples, (n = 28) 47% samples showed sensitivity towards Cefepime. These findings suggested that some mechanism or genetic mutations are there which inducing resistance in Escherichia coli towards antibiotics. There is an urgent need to control such alarming resistance

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