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Paper Details

Making MIC Work for You: Utilizing PK and PD Parameters

Dharmendra Sharma and Ashok Rattan.

Journal Title:Acta Scientific Microbiology

MIC or MBC has been used as indicator of antibiotic potency towards a pathogen and as surrogate marker for clinical efficacy when the selected antibiotic is used in the patient, but these parameters are static measures and do not adequately reflect the dy-namic process that takes place in a patient. To better predict the clinical efficacy of the drug we need to take into consideration the pharmacokinetics (what the host does to the drug) and the pharmacodynamics (what the drug does to the bug) and to obtain the three PK/PD parameters each of which depends upon the MIC value obtained but better predictive the clinical efficacy of the selected antibiotic.