Impact of serum level of vitamin D on term neonates with early onset sepsis
Yasmine Soliman 1; Magdy Sakr2; Tarek Emran 3; Mohamed El Samanoudy2
1Pediatrics Department, Faculty of Medicine, Mansoura university, Egypt
2Pediatrics Department, Damietta Faculty of Medicine, Al-Azhar University, Egypt.
3Clinical Pathology Department, Damietta Faculty of Medicine, Al-Azhar University, Egypt.
Journal Title:International Journal of Medical Arts
Background: Neonatal sepsis a major health challenge associated with major morbidity and mortality. Neonatal care improved recently. However, different challenges regarding management still exist. Vitamin D deficiencies was proposed as a predictor of neonatal sepsis.
Objective: To highlight the impact of vitamin D levels on early onset sepsis in full term neonates.
Methodology: It is a case control which carried out at the neonatal intensive care unit of Al-Azhar university hospital (Damietta), from March to April 2019. It included 50 full-term neonates with probable sepsis and 50 healthy controls of matched age and sex with no signs of sepsis.
Results: vitamin D level showed significant negative correlation with sepsis, C-reactive protein (CRP), positive blood cultures; and significant positive correlations with Apgar score, hemoglobin concentration and platelets count. Regression analysis revealed that, higher CRP and lower vitamin D were associated risks of neonatal sepsis in univariate analysis. Multivariable regression analysis revealed that only lower vitamin D level is the predictor for early neonatal sepsis.
Conclusion: Vitamin D levels were significantly lower in septic neonates with high sensitivity and specificity. Vitamin D supplementation to mothers during pregnancy could prevent early onset neonatal sepsis.